by Darren J. Baker et al. DOI: 10.1038/nature16932
The investigators employed a novel transgenic INK-ATTAC murine model to elucidate the physiological aspects and consequences of naturally occurring senescent cells. This research paper describes the anti-aging effect AP20187-based p16-positive cells clearance and the perspective of employing the treatment to annihilate age-related diseases.
p16Ink4a-expressing cells accumulation has detrimental effects on proper organs function in murine models. AP-based treatment in ATTAC mice has a great potential in diminishing age-related changes. However, it is still not clear, how AP influences wound healing and what is the most effective endurance of AP injections administration to attain the best results.
— Marina Ryabinina 2019/05/01 12:55