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Naturally Occurring p16Ink4a-Positive Cells Shorten Healthy Lifespan

by Darren J. Baker et al. DOI: 10.1038/nature16932


The investigators employed a novel transgenic INK-ATTAC murine model to elucidate the physiological aspects and consequences of naturally occurring senescent cells. This research paper describes the anti-aging effect AP20187-based p16-positive cells clearance and the perspective of employing the treatment to annihilate age-related diseases.

Key findings

  • p16Ink4a-positive cells were determined as generators of adipose tissue formation disruption, cataract formation, cardiac stress tolerance deterioration and glomerulosclerosis.
  • INK-ATTAC related AP20187 injection was used to promote apoptosis of p16Ink4a-positive cells of wild type mice from two cohorts with different diet, genetical background and dosing schedule.
  • Clearance of p16Ink4a- expressing cells had an anti-tumorigenic potential and diminished senescence-associated detrimental effect on observed organs (kidney, heart, fat and eye) without any vital functions disruption.
  • AP-treatment was ineffective when administered to unmanipulated mice.
  • AP-treatment seemed to deteriorate wound healing process.


p16Ink4a-expressing cells accumulation has detrimental effects on proper organs function in murine models. AP-based treatment in ATTAC mice has a great potential in diminishing age-related changes. However, it is still not clear, how AP influences wound healing and what is the most effective endurance of AP injections administration to attain the best results.

Marina Ryabinina 2019/05/01 12:55

research-review/naturally-occurring-p16ink4a-positive-cells-shorten-healthy-lifespan.txt · Last modified: 2019/07/17 03:41 by marcos