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research-review:fat-apoptosis-through-targeted-activation-of-caspase-8-a-new-mouse-model-of-inducible-and-reversible-lipoatrophy
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Fat Apoptosis Through Targeted Activation of Caspase 8: A New Mouse Model of Inducible and Reversible Lipoatrophy
20050619
Pajvani UB1, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE.
https://www.ncbi.nlm.nih.gov/pubmed/15965483
Introduction
Researchers genetically modified mice to have a specific protein, FKBP, on the surface of fat cells. These mice grow up just like normal mice. However, upon administering an agent, at any time during their life, these mice lose almost all of their fat cells.
The protein FKBP does not normally dimerize, or join together in pairs, but can be caused to dimerize in the presence of FK1012.
Thus, the surface of the fat cells, having the FKBP protein, can be dismantled using the dimerizing agent FK1012-analog. When this happens, the mouse loses fat cells and becomes a very lean mouse. Mice with the inducible fat loss were given the name FAT-ATTAC mice.
Points of Interest
- Caspases, are normally involved in the execution of cell apoptosis. Researchers modified the caspases to include the FKBP protein.
- After 2 weeks of administering the dimerizing agent, the blood stream showed near knockout levels of cell signaling proteins normally produced by fat cells, such as leptin and other adipokines.
- Compared to genetically modified mice used in previous studies, FAT-ATTAC mice are better subjects for study because they recover from the fat loss and become normal again.
(UNDER CONSTRUCTION)
— Marcos Reyes 2019/07/15 02:56
research-review/fat-apoptosis-through-targeted-activation-of-caspase-8-a-new-mouse-model-of-inducible-and-reversible-lipoatrophy.1564073587.txt.gz · Last modified: 2019/07/25 16:53 by marcos
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