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research-review:fat-apoptosis-through-targeted-activation-of-caspase-8-a-new-mouse-model-of-inducible-and-reversible-lipoatrophy
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Fat Apoptosis Through Targeted Activation of Caspase 8: A New Mouse Model of Inducible and Reversible Lipoatrophy
20050619
Pajvani UB1, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE.
https://www.ncbi.nlm.nih.gov/pubmed/15965483
Introduction
Researchers genetically modified mice to have a specific protein, FKBP, on the surface of fat cells. These mice grow up just like normal mice. However, upon administering an agent, at any time during their life, these mice lose almost all of their fat cells.
The protein FKBP does not normally dimerize, or join together in pairs, but can be caused to dimerize in the presence of FK1012-analog.
Thus, the surface of the fat cells, having the FKBP protein, can be dismantled using the dimerizing agent FK1012-analog. When this happens, the mouse loses fat cells and becomes a very lean mouse.
Points of Interest
Caspases are normally involved in the execution of cell apoptosis.
(UNDER CONSTRUCTION)
— Marcos Reyes 2019/07/15 02:56
research-review/fat-apoptosis-through-targeted-activation-of-caspase-8-a-new-mouse-model-of-inducible-and-reversible-lipoatrophy.1563996510.txt.gz · Last modified: 2019/07/24 19:28 by marcos
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