* Amalio Telenti, 1,2, * Brad A. Perkins, 1, * and J. Craig Venter, 1,2, *
1 Human Longevity Inc., San Diego, CA 92121, USA
2 J. Craig Venter Institute, La Jolla, CA 92037, USA
*Correspondence: [email protected] (A.T.), [email protected] (B.A.P.), [email protected] (J.C.V.)
Individuals may have a “genome burden”, which includes common and rare variant genes that accelerate aging through disease. Centenarians seem to live longer because they have a lower prevalence of these genes. “It is tempting to speculate that the dynamic process of decay of the somatic genome may be a stronger predictor of aging than hard-coded features of the germline genome.” The article fails to state what percentage of the population have common and rare gene variants.
— Marcos Reyes 2019/04/07 04:09