Judith Campisi. Science Vol 289. Sciencemag.org.
Calorie restriction slows down entropy in a cell lineage. CR increases SIR2p activity, which maintains heterochromatin, which protects DNA.
— Marcos Reyes 2019/04/04 12:07
“Although ERC formation has been widely suggested to drive ageing in yeast, there is little mechanistic data regarding the potential pathological activity of ERCs. It seems very likely to us that one result of rDNA amplification through ERC accumulation is to titrate histones and histone binding factors, and this will provide an important focus for future studies into age-linked gene expression change.” (Cruz et al 2018 https://elifesciences.org/articles/34081)