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research-review:fat-apoptosis-through-targeted-activation-of-caspase-8-a-new-mouse-model-of-inducible-and-reversible-lipoatrophy [2019/09/04 01:24] marcos [Points of Interest] |
research-review:fat-apoptosis-through-targeted-activation-of-caspase-8-a-new-mouse-model-of-inducible-and-reversible-lipoatrophy [2020/05/05 05:53] marcos [Abstract] |
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The protein FKBPv is part of a [[https://en.wikipedia.org/wiki/Caspase |Caspase]]. Caspases are used to invoke [[https://en.wikipedia.org/wiki/Programmed_cell_death |programmed cell death]], a natural occurring phenomena. | The protein FKBPv is part of a [[https://en.wikipedia.org/wiki/Caspase |Caspase]]. Caspases are used to invoke [[https://en.wikipedia.org/wiki/Programmed_cell_death |programmed cell death]], a natural occurring phenomena. | ||
- | <hidden>[[https://en.wikipedia.org/wiki/Caspase |Caspases]] are [[https://www.britannica.com/science/proteolytic-enzyme |proteolytic enzymes]] (also called proteases or peptidases). Proteases are molecules that disassemble other molecules into smaller ones, a process called [[https://en.wikipedia.org/wiki/Catabolism |Catabolism]].</hidden> | + | <hidden Click to understand caspases.>[[https://en.wikipedia.org/wiki/Caspase |Caspases]] are [[https://www.britannica.com/science/proteolytic-enzyme |proteolytic enzymes]] (also called proteases or peptidases). Proteases are molecules that disassemble other molecules into smaller ones, a process called [[https://en.wikipedia.org/wiki/Catabolism |Catabolism]].</hidden> |
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Caspase 8 exists in a cell as inactive pairs, and need to be triggered to become active. Caspases can be activated by the [[https://en.wikipedia.org/wiki/Caspase#Activation_of_caspases |removal of the prodomain]], in this case FKBPv. FKBPv does not normally [[https://en.wikipedia.org/wiki/Dimer_%28chemistry%29 |dimerize]], or join together in pairs, but can be caused to dimerize in the presence of an [[https://en.wikipedia.org/wiki/FK1012 |FK1012]] analog. Inactive Caspase pairs then merge in the process and begin to sever peptide bonds of the cell. | Caspase 8 exists in a cell as inactive pairs, and need to be triggered to become active. Caspases can be activated by the [[https://en.wikipedia.org/wiki/Caspase#Activation_of_caspases |removal of the prodomain]], in this case FKBPv. FKBPv does not normally [[https://en.wikipedia.org/wiki/Dimer_%28chemistry%29 |dimerize]], or join together in pairs, but can be caused to dimerize in the presence of an [[https://en.wikipedia.org/wiki/FK1012 |FK1012]] analog. Inactive Caspase pairs then merge in the process and begin to sever peptide bonds of the cell. |