research-review:aging-converts-innate-b1a-cells-into-potent-cd8-t-cell-inducers
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research-review:aging-converts-innate-b1a-cells-into-potent-cd8-t-cell-inducers [2020/01/11 04:21] marcos [Summary (tldr;)] |
research-review:aging-converts-innate-b1a-cells-into-potent-cd8-t-cell-inducers [2020/05/05 06:33] (current) marcos |
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| - | // This article will be discussed on November 14th at [[http://www.biotechwithoutborders.org/|Biotech without Borders]] as part of the [[https://www.meetup.com/New-York-Science-Journal-Club/events/265786265/|Deep Dive]] series. // | + | --- // This article will be discussed on November 14th at [[http://www.biotechwithoutborders.org/|Biotech without Borders]] as part of the [[https://www.meetup.com/New-York-Science-Journal-Club/events/265786265/|Deep Dive]] series. // |
| // In the context of the review which this paper is paired with for Deep Dive, this is an example of "altered intercellular communication". Specifically this is about the immune system behaving differently over time that is referred to as immunosenecence. // | // In the context of the review which this paper is paired with for Deep Dive, this is an example of "altered intercellular communication". Specifically this is about the immune system behaving differently over time that is referred to as immunosenecence. // | ||
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| It may be helpful to know what the various ligands are so here's a table: | It may be helpful to know what the various ligands are so here's a table: | ||
| - | ++++ after making it I realized it's pretty big, and maybe not entirely helpful so I hid it. But please feel free to familiarize yourself :P | | + | |
| + | <hidden After making it I realized it's pretty big, and maybe not entirely helpful so I hid it. But please feel free to familiarize yourself :P> | ||
| ^ Ligand short ^ Full name ^ Location ^ Species specificity (used in this study) ^ Short description ^ | ^ Ligand short ^ Full name ^ Location ^ Species specificity (used in this study) ^ Short description ^ | ||
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| | CD21/35 | Complement C3d/C3b/C4b receptor | extra- | mouse | allows complement signals to pass to B-cells | | | CD21/35 | Complement C3d/C3b/C4b receptor | extra- | mouse | allows complement signals to pass to B-cells | | ||
| | CD1d | Cluster of differentiation 1, group 2 | extra- | mouse | primarily a marker for natural killer cells, quite mysterious | | | CD1d | Cluster of differentiation 1, group 2 | extra- | mouse | primarily a marker for natural killer cells, quite mysterious | | ||
| - | + | </hidden> | |
| - | + | \\ | |
| - | ++++ | + | |
| If one thing can be gleaned from this section on labelling it may be that there are many cells involved in the immune system. A typical basic research programme defines the cells they are studying using antibodies to label cells. As more studies are performed on different subsets more functional data becomes linked to various molecular identities and more mechanistic theories about the larger system can be proposed. | If one thing can be gleaned from this section on labelling it may be that there are many cells involved in the immune system. A typical basic research programme defines the cells they are studying using antibodies to label cells. As more studies are performed on different subsets more functional data becomes linked to various molecular identities and more mechanistic theories about the larger system can be proposed. | ||
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| ===== Discussion ===== | ===== Discussion ===== | ||
| + | --- //[[user:danny|Daniel Chan]] 2020/01/13 19:23// | ||
research-review/aging-converts-innate-b1a-cells-into-potent-cd8-t-cell-inducers.1578716467.txt.gz · Last modified: 2020/01/11 04:21 by marcos
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